Das deklarative Gedächtnis bei Schizophrenie
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Kognitive Funktionen sind eng mit der Funktion bestimmter Bereiche, neuronaler Bahnen oder kortikaler Netzwerke in den Substratschichten der neurologischen Matrix auf zellul�rer und molekularer Ebene verbunden. Schizophrene weisen zudem ein breites Spektrum an kognitiven Beeintr�chtigungen auf, darunter Leistungsst�rungen in den Bereichen Aufmerksamkeit, Informationsverarbeitung, exekutive Funktionen, Ged�chtnis und Sprachf�higkeiten. Beeintr�chtigungen der Aufmerksamkeit und des verbalen Ged�chtnisses werden als Vulnerabilit�tsmarker konzeptualisiert, die bei der Definition des Schizophrenie-Ph�notyps hilfreich sein k�nnen, f�r die Fr�herkennung geeignet sind und eine Grundlage f�r die Entwicklung neuer Behandlungsmodelle bieten. Ziel der vorliegenden Studie war es, das deklarative Ged�chtnis bei Patienten mit paranoider und undifferenzierter Schizophrenie auf der Grundlage des PART unter Verwendung von WCST-Reizen zu bewerten. Die Ergebnisse zeigten, dass die exekutiven Funktionen und das deklarative Ged�chtnis von Schizophrenen im Vergleich zu gesunden Probanden beeintr�chtigt sind. Innerhalb der Schizophrenie-Untergruppen ist die gr� te Beeintr�chtigung bei Patienten mit undifferenzierter Schizophrenie zu beobachten. Dieses Buch kann eine hervorragende Informationsquelle f�r alle Forscher im Bereich der kognitiven Rehabilitation sein, die dazu beitragen kann, die Lebenskompetenzen von Schizophreniepatienten zu verbessern.
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