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Depression und Suizid by Emily Chen

Depression und Suizid

by Emily Chen
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Book cover type: Paperback
  • ISBN13: 9786209509919
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 38.19
  • Language: German
  • Edition: N/A
  • Item Weight: 109 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

Die Major Depression (MDD) ist eine der am schwierigsten zu untersuchenden psychiatrischen Erkrankungen. Es handelt sich um eine polygene Erkrankung mit einer Lebenszeitpr�valenz von 10-15 %, wobei Frauen aus unbekannten Gr�nden doppelt so h�ufig betroffen sind wie M�nner. Die hohe Lebenszeitpr�valenz dieser nicht infekti�sen, aber stark beeintr�chtigenden Erkrankung erfordert Fortschritte auf diesem Gebiet, damit bessere Therapeutika entwickelt werden k�nnen, um Patienten wirksamer zu behandeln. Genomweite Assoziationsstudien zur Major Depression haben bislang noch keine signifikanten Ergebnisse geliefert. Dies liegt wahrscheinlich daran, dass die Auswirkungen einzelner Loci gering sind und/oder dass die Heterogenit�t der Erkrankung hoch ist. Die Beteiligung nicht-genetischer Faktoren wie Umweltvariablen ist ein weiterer komplizierender Faktor. Infolgedessen ist die Entschl�sselung der genetischen Architektur schwierig. Obwohl sowohl Gene als auch die Umwelt Faktoren f�r die Entwicklung einer MDD sind, konzentriert sich dieses Buch auf die Genetik der Erkrankung. Es besteht ein dringender Bedarf, die genetischen Grundlagen der MDD zu verstehen, und es ist unser Ziel, dies mithilfe von Next-Generation-Sequencing zu erreichen, um die genomischen Varianten und dysregulierten Gene zu entdecken, die bei ihrer Entwicklung eine Rolle spielen.

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