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Développement Du Pancréas by Elghazi-Cras-L

Développement Du Pancréas

by Elghazi-Cras-L
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Book cover type: Paperback
  • ISBN13: 9786131556470
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 140
  • Original Price: GBP 41.0
  • Language: French
  • Edition: N/A
  • Item Weight: 214 grams
  • BISAC Subject(s): Life Sciences / Biology

Chez le rat, le pancréas se développe à partir de bourgeonnements de l'épithélium digestif qui vont croître et se ramifier dans le mésenchyme environnant. Les cellules épithéliales vont ensuite proliférer et se différencier en cellules exocrines ou endocrines. Ces étapes de prolifération et de différenciation sont contrôlés par des facteurs mésenchymateux dont la nature reste inconnue. Dans un grand nombre d'organes dont le pancréas, des récepteurs à activité tyrosine kinase sont impliqués dans les interactions entre l'épithélium et le mésenchyme. Ils prennent part à diverses réponses biologiques. Notre objectif, a été d'identifier des ligands de ces récepteurs potentiellement impliqués dans le développement du pancréas en termes de prolifération et de différenciation. En conclusion, nos travaux nous ont permis d'identifier le rôle de certains ligands (HGF, EGF, FGF) de récepteurs à activité tyrosine kinase dans le développement pancréatiques et particulièrement leur implication dans le contrôle de la prolifération des cellules précurseurs pancréatiques.

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