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Développements de Méthodes Clhp by Collectif

Développements de Méthodes Clhp

by Collectif
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Book cover type: Paperback
  • ISBN13: 9786131539916
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 208
  • Original Price: GBP 60.0
  • Language: French
  • Edition: N/A
  • Item Weight: 313 grams
  • BISAC Subject(s): Chemistry / General

Les recherches de développement analytique de cet ouvrage s'inscrivent dans le cadre d'un projet de développement durable nommé ARIamal. Ce projet consiste au développement d'une co-formulation pédiatrique, visant à traiter les accès fébriles sévères en milieu tropical, provoqués par les infections respiratoires aigues et le paludisme. Ainsi, plusieurs méthodes ont été développées pour l'analyse des couples à l'essai, artéméther/azithromycine et artésunate/azithromycine, dans leur forme pharmaceutique, respectivement un suppositoire et une gélule rectale. Les méthodes consistent en de la CLHP en phase inverse. Le mode de détection utilisé est l'UV ou le DEDL.Ces méthodes ont été validées selon le guide ICH Q2 (R1) basé sur l'étude de la spécificité d'une part et la notion d'erreur totale et l'élaboration du profil d'exactitude, d'autre part.De plus, la capacité de ces méthodes à doser de manière univoque les principes actifs, en présence de nombreux produits de dégradation, a été démontrée grâce à des études de stabilité forcée menées sur 24H. Ces études ont aussi permis d'évaluer la compatibilité des principes actifs et leur stabilité en diverses conditions stressantes.

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