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Développements en phylogénomique by Helaers-R

Développements en phylogénomique

by Helaers-R
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Book cover type: Paperback
  • ISBN13: 9783841780638
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 188
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 282 grams
  • BISAC Subject(s): Life Sciences / Biology

Cette thèse présente les développements bioinformatiques ayant abouti à la création de 2 logiciels. Tout d'abord, nous plongerons dans l'inférence phylogénétique, présentant un état de l'art du domaine puis en détaillant l'implémentation de MetaPIGA 2, un logiciel qui permet d'inférer une phylogénie via l'utilisation de méta-heuristiques. Quatre méta-heuristiques ont été adaptées pour cette problématique: un hill climbing, un recuit simulé, un algorithme génétique et l'algorithme génétique méta-populationnel. Ensuite, nous mettrons en avant une approche phylogénétique pour la génomique comparative, en développant le logiciel MANTiS, qui permet d'explorer le contenu d'une sélection de génomes eucaryotes le long d'une phylogénie. Nous y expliquerons comment les relations d'homologie sont identifiées à l'aide d'arbres phylogénétiques, et comment nous pouvons suivre l'historique des événements de duplication au cours de l'évolution, déterminer quand un caractère a été gagné et perdu, reconstituer le contenu des génomes ancestraux, et étudier l'évolution fonctionnelle d'un génome au cours du temps. Cet ouvrage s'adresse aussi bien à qui s'intéresse à la biologie et/ou à l'informatique.

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