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Diagnostic de la maladie de Hirschsprung by Jouini, Raja

Diagnostic de la maladie de Hirschsprung

by Raja Jouini , Imen Helal , Sarra Yacoub
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Book cover type: Paperback
  • ISBN13: 9786206729853
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Universitaires Europeennes
  • Publisher Imprint: Editions Universitaires Europeennes
  • Publication Date:
  • Pages: 92
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 137 grams
  • BISAC Subject(s): General

La maladie de Hirschsprung (MH) est une maladie congénitale rare définie par l'absence de cellules ganglionnaires (CG) dans un segment du tube digestif. Son diagnostic en Tunisie repose uniquement sur l'étude histopathologique à l'hématéine éosine. Actuellement, plusieurs études sont menées sur des biomarqueurs de la MH, notamment sur l'anticorps anti-calrétinine. L'objectif de notre travail était d'évaluer la performance diagnostique de l'anticorps anti-calrétinine dans le cadre de suspicion d'une MH. Il s'agissait d'une étude rétrospective incluant 69 patients porteurs d'une MH. Une étude immunohistochimique avec l'anticorps anti-calrétinine a été faite. Au niveau des biopsies faites en ZPM, les CG ont été marquées dans 2 biopsies alors que les fibres nerveuses interstitielles ont été marquées dans 3 biopsies. La sensibilité, la spécificité, la valeur prédictive positive et la valeur prédictive négative de l'anticorps anti- calrétinine était respectivement de 93%, 100%, 100% et 70%. Le recours à une étude immunohistochimique avec l'anticorps anti-calrétinine en l'absence de CG constitue une alternative raisonnable devant les implications thérapeutiques graves de la MH.

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