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Diagnostic et traitement des leucémies aiguës lymphoblastiques by Fakhfakh, Yousra

Diagnostic et traitement des leucémies aiguës lymphoblastiques

by Yousra Fakhfakh , Imen Frikha
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Book cover type: Paperback
  • ISBN13: 9786206722038
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Universitaires Europeennes
  • Publisher Imprint: Editions Universitaires Europeennes
  • Publication Date:
  • Pages: 204
  • Original Price: GBP 67.0
  • Language: French
  • Edition: N/A
  • Item Weight: 304 grams
  • BISAC Subject(s): General

La LAL a reconnu des progrès thérapeutiques significatifs chez l'enfant. Cependant, chez l'adulte, les résultats sont encore non satisfaisants. Nos résultats sont cependant moins encourageants. Évaluer les résultats du protocole GRAALL et GRAAPH dans le traitement des LAL de l'adulte et proposer un algorithme thérapeutique adapté aux facteurs pronostiques validés chez nos patients.Notre étude est rétrospective. Elle a inclus les adultes suivis pour une LAL diagnostiquée au service d'hématologie du CHU Hédi Chaker de Sfax. Nous avons étudié les caractéristiques diagnostiques, les résultats thérapeutiques, évolutifs et les facteurs pronostiques de notre population.Nous avons colligé 49 patients, avec un sex ratio de 0,88. La médiane d'âge était de 42 ans. Une hyperleucocytose >30 G/l était constatée chez 28% des cas. Il s'agit de LAL-B dans 65% des cas, de LAL-T dans 33% des cas et biphénotypique dans 2%. Le caryotype était concluant dans 70%, dont 54% avaient des anomalies cytogénétiques. Le taux global de RC étaitde 93% pour les LAL non-phi+ et de 90% pour les LAL phi+, celui d'échec était respectivement de 5% et 10%.

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