Die Endokrine Behandlung Des Mamma- Und Prostatacarcinoms: Endokrine Regulationen Des Kohlenhydratstoffwechsels
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Die Behandlung von 113 an metastasierendem Mammacarcinom erkrankten Frauen mit Nortestosteron-Phenylpropionat (Durabolin-Organon) ergab ein gün- stiges Resultat bei 40 Patientinnen (35,4%). 77 Patientinnen standen vorher unter Testosteronbehandlung, bis sich der Testosteron-Effekt erschöpft hatte. In diesen Fällen konnte mit Durabolin noch bei 35% ein günstiges Resultat erzielt werden. Unter 40 Patientinnen, die noch nicht mit Testosteron vorbehandelt waren, fanden sich 45% günstig reagierende Fälle. Die Dauer der Verbesserungen mit Nortesto- steron-Phenylpropionat betrug rund 10 Monate, auch wenn zu einem früheren Zeitpunkt Testosteronpräparate verabfolgt worden waren. Die Nebenwirkungen der Durabolin-Therapie waren unbedeutend. Eine gewisse Korrelation zwischen der Erniedrigung des oestrogenen Effektes im Vaginalausstrich und einer klini- schen Verbesserung scheint aus den bisherigen Befunden möglich zu sein. Nach sehr vorläufigen Erfahrungen hat Nortestosteron-Decanoat in 4 von 15 Patientinnen mit metastasierendem Brustcarcinom eine günstige Wirkung gezeigt. Literatur 1. GELLHORN, A.: Edit. Symposium on hormones and cancer therapy. (A. KmscHBAuM, R. HERTZ, R. I. DORFMAN, S. G. TAYLOR, B. J. KENNEDY, R. LUFT a. 0.): Amer. J. med. 21, (1956). 2. GERBRANDY, J. H., and H. HELLENDOORN: Ned. T. Geneesk. 101, 1257 (1957). 3. HORTLlNG, H., K. MALMIO, L. HrrsI-BRuMMER and G. AF BJÖRKESTEN: Proc. of the Ed- burgh Meeting of Endocrinology, Aug. 1959. 4. LUFT, R., H. OLIVECRONA and D. IKKos: Acta endocr. (Kbh.) 31, 241 (1957). 4a. MALMIO, K., L. HnsI-BRuMMER and H. HORTLING: Ann. Med. int. Fenn. 49, 121 (1960). 5. MEYER, A.: Acta Biochim. biophys. 17,441 (1955).
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