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Dissertação final by Benabdellah, Karima

Dissertação final

by Karima Benabdellah , Chabha Meghni , Fatma Kessal
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Book cover type: Paperback
  • ISBN13: 9786207636174
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 60
  • Original Price: GBP 52.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 100 grams
  • BISAC Subject(s): Pharmacology

A monitorização molecular dos níveis de transcrição de BCR-ABL por PCR quantitativa é cada vez mais utilizada para avaliar a resposta dos doentes ao tratamento. Isto tornou-se particularmente interessante na era do imatinib, quando a doença residual fica abaixo do limiar de deteção da citogenética convencional. O principal objetivo do nosso trabalho é estudar a evolução da LMC através da quantificação do transcrito molecular BCR/ABL durante a fase terapêutica. Trata-se de um estudo retrospetivo e descritivo de 30 doentes seguidos no serviço de hematologia do CHU de Tizi Ouzou, na unidade de consulta. O seguimento molecular mostrou que 70% dos doentes tiveram MMR com imatinib 400 mg e 20% dos doentes que falharam o imatinib 400 e 600 mg foram substituídos por um TKI de segunda geração com MMR de 100%. A quantificação do rácio BCR/Abl mostrou que 96% dos doentes que tomaram imatinib 400 mg ficaram curados. Em conclusão, para otimizar o tratamento e a utilização dos vários TKI disponíveis, é necessário estabelecer uma monitorização biomolecular dos transcritos BCR/Abl no momento do diagnóstico.

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