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DNA Repair and Recombination by T. R. Lindahl, S. C. West, Lindahl

DNA Repair and Recombination

by T. R. Lindahl , S. C. West , Lindahl
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Book cover type: Hardcover
  • ISBN13: 9780412640407
  • Binding: Hardcover
  • Subject: N/A
  • Publisher: Kluwer Academic Publishers
  • Publisher Imprint: Kluwer Academic Publishers
  • Publication Date:
  • Pages: 103
  • Original Price: USD 99.0
  • Language: English
  • Edition: N/A
  • Item Weight: 604 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

Genomic instability is a major threat to living organisms. To counteract the damaging effects posed by endogenous and environmental agents, such as chemicals or radiation, micro-organisms devote several percent of their genome to encode proteins that function in the repair and recombination of DNA. For many years, a relatively small group of scientists have carefully delineated the molecular mechanisms of these repair processes, using the simplest model systems available, namely Escherichia coli and Saccharomyces cerevisiae. These studies, which until recently had only moderate impact outside of the field, now provide the cornerstone for exciting new research into analogous processes in human cells. The reason for this is the revelation that the biochemical pathways for the accurate replication, repair and recombination of DNA have been conserved through evolution.

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