Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field
Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes.
The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine.
Readers will also benefit from the inclusion of: *A thorough introduction to the utility of mathematical models in drug development and delivery *An exploration of the techniques and applications of physiologically based models to drug delivery *Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery *A review of integrated transdermal delivery and pharmacokinetics in development *An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms *Alternative endpoints to pharmacokinetics for topical delivery
Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Bret Berner, PhD, is a pharmaceutical consultant in drug delivery, formulation, and pharmacokinetics. He was formerly Director of Basic Pharmaceutics Research at Ciba-Geigy, Vice President of Development at Cygnus Therapeutics, and Chief Scientific Officer at Depomed.
Toufigh Gordi, PhD, is a Senior Director of clinical pharmacology at Rigel Pharmaceuticals, with extensive experience in using pharmacokinetic and pharmacodynamic modeling to advance candidate drug molecules from preclinical through late phase confirmatory clinical studies.
Heather A. E. Benson, PhD, is Associate Professor in Curtin Medical School at Curtin University, Australia where she leads the Skin Delivery Research Group
Michael S. Roberts, PhD, is Professor of Therapeutics and Pharmaceutical Science at the University of South Australia and Professor of Clinical Pharmacology and Therapeutics at the University of Queensland.
