Efeitos do DON e do DOM-1 na função das células da teca ovariana bovina

Name: Efeitos do DON e do DOM-1 na função das células da teca ovariana bovina
Brand: Edicoes Nosso Conhecimento
SKU: 9786630003338
Price: 5317.0 INR
Availability: InStock

by Mohammadali Torabi , Fatemeh Aminmarashi

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ISBN13: 9786630003338
Binding: Paperback
Subject: N/A
Publisher: Edicoes Nosso Conhecimento
Publisher Imprint: Edicoes Nosso Conhecimento
Publication Date: May 22, 2026
Pages: 72
Original Price: GBP 42.0
Language: Portuguese
Edition: N/A
Item Weight: 109 grams
BISAC Subject(s): General

About The Book

A micotoxina desoxinivalenol (DON) e o seu metabolito deepoxi-DOM-1 t�m efeitos significativos na fun��o das c�lulas da teca ovariana bovina. O objetivo deste estudo foi identificar as diferentes vias de sinaliza��o envolvidas no mecanismo de a��o do DON e do DOM-1 atrav�s da espectrometria de massa. M�todos: as c�lulas da teca ovariana bovina foram colhidas de vacas adultas, independentemente da fase do ciclo estral, e foram cultivadas a uma densidade de 500 000 c�lulas vi�veis em 1 ml de meio de McCoy durante 5 dias. As c�lulas foram ent�o tratadas no 5. dia de cultura com 1 ng/mL de DON ou DOM-1 durante 30 minutos e a prote�na celular total foi recolhida para espectrometria de massa. Os resultados da espectrometria de massa mostraram que tanto o DON como o DOM-1 induzem a regula��o positiva simult�nea de ERK1/2, MAPK14 (p38alfa) e MAPK13 (p38delta). A espectrometria de massa indicou tamb�m que 94 pept�deos, tais como GNGT1, EDN1 e YWHAB, foram regulados positivamente. Estes regulam principalmente as vias de prolifera��o celular e est�o envolvidos na bioss�ntese de l�pidos e hidratos de carbono. No entanto, 255 pept�deos, tais como CALR3, PTGES3, RAD21, ACVR2B e TGFBR1, foram regulados negativamente, sendo que as suas atividades consistem principalmente na ativa��o ou desativa��o de processos apopt�ticos e no metabolismo da glicose e da colina.

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