Epidemiologische Untersuchung Über Die Häufigkeit Der Bakteriellen Niereninfektion in Der Bevölkerung
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In einer prospektiven Studie in der Bevolkerung der Stadt Munster und Umgebung wurde versucht, das moderne diagnostische Instrumentarium der Nephrologie fur eine erfolgreiche Fruherkennung und Besserbewertung von Nierenschaden einzusetzen. Gleichzeitig wurde versucht, eine zuverlassige Zahl uber tatsachliche Nierenschaden mit besonderer Berucksichtigung der bakteriellen Infektionen in der Bevolkerung zu erzielen. Dabei wurde nachgewiesen, daB insgesamt in der Bevolkerung Nierenschaden, primar und sekundar in ungewohnlicher Haufigkeit (30 %), existieren. Eine bakterielle Besiedelung der ableitenden Harnwege konnte nur bei 3,7 Prozent der unt- suchten Bevolkerungsgruppe nachgewiesen werden, wobei nur bei der Halfte dieser Probanden Hinweise auf eine tatsachliche Erkrankung der Nieren oder des ableitenden Harntraktes erfaBt wurden. Diese Er- gebnisse legen nahe, die bisher ublichen Vorsorge- untersuchungen durch die molekulargewichtsbezogene Proteinanalyse zu erweitern und auf eine groBere Bevolkerungsgruppe auszudehnen, um behandelbare Erkrankungen der Nieren und der ableitenden Harn- wege rechtzeitig zu erkennen. Eine prazise Aussage uber den besten Zeitpunkt einer solchen Vorsorge- untersuchung erhoffen wir von der abschlieBenden Analyse der Population im Kindergartenalter hier im Einzugsbereich der Stadt Munster. - 26 - Abb.: 1 a + b Molekulargewichtsbezogene Proteinanalyse (PAGE) im Urin 1 normales Muster 2 TubulusUision 3 glom. und tubulare Lasion 4 Serum-Kontrolle 2 4 Immunglobuline Transferrin Albumin niedermolekulare Proteine 3 4 - 27 - TAB ELL E N Geschlechtsverteilung n = % 537 51,0 mannlich weiblich 515 48,9 0, 1 keine Angabe 2 Total 1054 100,0 ( POP 78 / 80 ) Tab.
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