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Epithelial-Mesenchymal Transition: Cancer's Pathway to Spread by Nikita Kashyap

Epithelial-Mesenchymal Transition: Cancer's Pathway to Spread

by Nikita Kashyap , Jay Gopal Ray , Aravindan S
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Book cover type: Paperback
  • ISBN13: 9786208422059
  • Binding: Paperback
  • Subject: N/A
  • Publisher: LAP Lambert Academic Publishing
  • Publisher Imprint: LAP Lambert Academic Publishing
  • Publication Date:
  • Pages: 56
  • Original Price: GBP 38.19
  • Language: English
  • Edition: N/A
  • Item Weight: 87 grams
  • BISAC Subject(s): Dentistry / General

Epithelial-mesenchymal transition (EMT) is a vital biological process in which epithelial cells transform into mesenchymal cells, gaining migratory and invasive capabilities. This reversible process plays a critical role in embryonic development, wound healing, fibrosis, and cancer metastasis. EMT is regulated by key signaling pathways, including TGF-β, Wnt, and Notch, and orchestrated by transcription factors like Snail and Twist. In cancer, EMT facilitates invasion, metastasis, and therapy resistance, marking it as a significant factor in tumor progression. EMT also contributes to cancer stem cell formation and immune evasion. The interplay between EMT and mesenchymal-to-epithelial transition (MET) underscores cellular plasticity in metastasis, where cells revert to epithelial states in secondary sites. Recent advances in targeting EMT therapeutically-such as inhibitors of TGF-β and EMT transcription factors-offer hope for reducing metastasis and improving treatment outcomes. This work explores the molecular mechanisms and clinical implications of EMT, emphasizing its dual roles in physiology and pathology.

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