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Estudos de preparação e avaliação de microesferas de cefixima by Mallikarjun Vasam

Estudos de preparação e avaliação de microesferas de cefixima

by Mallikarjun Vasam
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Book cover type: Paperback
  • ISBN13: 9786209581885
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 68
  • Original Price: GBP 38.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 105 grams
  • BISAC Subject(s): Pharmacology

As microesferas de cefixima s�o formuladas para superar as desvantagens e eliminar os efeitos secund�rios da cefixima em formas farmac�uticas convencionais. As microesferas foram formuladas utilizando alginato de s�dio (3%, 4% e 5%) com copol�mero Carbopol P934 e HPMC K15M numa concentra��o de 1% e cloreto de c�lcio (3%) como agente de reticula��o pela t�cnica de gelifica��o i�nica por orif�cio. A formula��o das microesferas baseia-se na intera��o entre o pol�mero e o agente de reticula��o. O alginato de s�dio � um pol�mero ani�nico, que pode ser facilmente reticulado com cloreto de c�lcio, a complexa��o entre o �on Ca+2 e o alginato de s�dio para retardar a libera��o do f�rmaco. O tamanho das part�culas foi caracterizado por microscopia eletr�nica de varredura (MEV), e a compatibilidade dos excipientes farmac�uticos foi determinada por espectroscopia FTIR. Tamb�m foram realizados estudos sobre a percentagem de conte�do do f�rmaco, efici�ncia de encapsulamento, comportamento de fluxo, �ndice de expans�o e liberta��o in vitro do f�rmaco. Este livro fornecer� informa��es detalhadas sobre a prepara��o e os estudos de avalia��o das microesferas.

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