Etoposid (VP 16-213) in Der Therapie Maligner Erkrankungen: Präklinische Und Klinische Studien
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Der Anerkennung einer neuen Substanz als klinisch wirksames Chemotherapeutikum gehen jahrelange Studien voraus. Anfang der siebziger Jahre wurde die Antitumoraktivitat bestimmter Podophyllo- toxinderivate entdeckt. Die ungewohnlichen biologischen Eigenschaf- ten und die therapeutische Wirksamkeit dieser Derivate erweckten das Interesse von experimentellen und klinischen Forschern. Besonders E toposid (VP 16-213) erschien wegen seiner niedrigen und vorhersagba- ren Toxizitat vielversprechend fiir einen klinischen Einsatz. Tatsachlich zeigten die bisherigen Erfahrungen, daB das Praparat eine besondere Aktivitat bei bestimmten Formen akuter Leukamien, bei Non- Hodgkin-Lymphomen, bei Lungenkarzinomen und Hodentumoren entfaltet. - Urn einen Dberblick iiber den derzeitigen Stellenwert von VP16-213 zu gewinnen, wurden auf Anregung der I. Medizinischen Universitatsklinik Wien und in Zusammenarbeit mit der Osterreichi- schen Krebsgesellschaft und -Liga Arbeitsgruppen aus Osterreich, Deutschland, Holland und der Schweiz eingeladen, ihre bisherigen Er- fahrungen mit Etoposid auszutauschen und zu diskutieren. Ein zweita- giges Symposium in Baden bot dazu Gelegenheit. Das Resultat der ge- me ins amen Bemiihungen ist in diesem Band zusammengefafk Neben den Beitragen der einzelnen Autoren ist am Ende des jeweiligen Hauptkapitels der wesentliche Inhalt der Diskussionsbeitrage wiederge- geben. Diese komprimierte Darstellung war notwendig, urn den Leser nicht zu ermiiden und den Rahmen des Buches nicht zu sprengen. Unser besonderer Dank gilt Frau Dr. F. Schremmer, deren Einsatz und Umsicht wesentlich zum Gelingen der Publikation beigetragen hat. E. Deutsch K. Karrer J. D. Schwarz meier Diskussionslei ter Prof. Dr. H. Denck 1.
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