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Extraction of Artemisinin from Artemisia Annua: Extraction of Artemisinin by Seid Yimer

Extraction of Artemisinin from Artemisia Annua: Extraction of Artemisinin

by Seid Yimer
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Book cover type: Paperback
  • ISBN13: 9783656362104
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Grin Verlag
  • Publisher Imprint: Grin Verlag
  • Publication Date:
  • Pages: 92
  • Original Price: USD 63.5
  • Language: English
  • Edition: N/A
  • Item Weight: 132 grams
  • BISAC Subject(s): Industrial Technology

Bachelor Thesis from the year 2008 in the subject Engineering - Chemical Engineering, grade: A, Bahir Dar University (Bahir Dar University Engineering Faculity), course: Chemical Engineering, language: English, abstract: Abstract Malaria disease is endemic in least developed countries like Ethiopia. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The content of artemisinin is very small and from 0.5 to 1.2 % of dry weight of plants in Ethiopia. Extraction of artemisinin from Artemisia annua is mainly performed using hydrocarbon extraction processes. Extraction with Supercritical CO2, ethanol, ionic liquids, hydroflourocarbon HFC-134a and hexane extraction are extraction technologies and compared majorly in terms of their extraction efficiency, cost and drawback to environment. Since artemisinin is only present in the epidermis of the leaves, leaves were only washed on the outside by stirring appeared to be the most appropriate method and the first step in this research was solvent extraction using hexane. Step followed purify by repeated crystallization. Laboratory scale production data and procedures were listed for aremisinin extraction process. By using those data large scale production method was designed. And did material and energy balance calculations for large scale production process carried out by taking scientific approach followed by feasibility study. As a result my extractor was very large and it has 14.37m3 capacities it wasn't found in market. So I designed the required larger extractor that should fulfill the target of the project i.e. with simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from Artemisia annua. The design the extractor I used the optimum

My name is Seid Yimer. I was born in July 1986 in Tita, South Wollo Ethiopia.I got Master of Technology Degree in Chemical Engineering from Addis Ababa University and IIT - Delhi joint mater program in 2010 and B.Sc Degree from Bahir Dar University in Chemical Engineering in 2008.I have been lecturing in Chemical engineering Department, Kombolcha institute of technology, Wollo University, Ethiopia since Aug 201

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