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Factores de risco do carcinoma hepatocelular by Sherief Abd-Elsalam

Factores de risco do carcinoma hepatocelular

by Sherief Abd-Elsalam
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Book cover type: Paperback
  • ISBN13: 9786208318796
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 88
  • Original Price: GBP 52.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 141 grams
  • BISAC Subject(s): General

O carcinoma hepatocelular é multifatorial em termos de etiologia e complexo em termos de patogénese. A combinação de factores de risco difere em diferentes partes do mundo, o que pode explicar em parte as diversas caraterísticas biológicas do CHC em diferentes populações. O CHC é único na medida em que ocorre em grande parte num contexto estabelecido de doença hepática crónica e cirrose (70-90% de todos os casos detectados de CHC). O sexo masculino, a idade e a duração da cirrose são os principais factores de risco para o carcinoma hepatocelular em doentes cirróticos. A tendência crescente do CHC tem sido associada ao aumento da prevalência da infeção pelo vírus da hepatite C (VHC). O VHC é considerado um dos principais factores de risco para a progressão para cirrose hepática e CHC. A integração do ADN viral no genoma do hospedeiro foi sugerida como sendo o evento inicial da carcinogénese induzida pelo VHB. Alguns dados sugerem que a proteína HBx pode inativar o p53 (gene supressor de tumores), levando ao desenvolvimento de CHC. As aflatoxinas são micotoxinas que ocorrem naturalmente e que se encontram em diferentes alimentos, tendo sido demonstrado que são carcinogénicas.

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