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Formulazione di un sistema di somministrazione di farmaci auto-microemulsionante by Mohite, Popat

Formulazione di un sistema di somministrazione di farmaci auto-microemulsionante

by Popat Mohite , Vinayak Harischandre
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Book cover type: Paperback
  • ISBN13: 9786207863822
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 104
  • Original Price: GBP 42.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 164 grams
  • BISAC Subject(s): Pharmacology

In questo libro viene illustrato un metodo per preparare un sistema di rilascio di farmaci auto-microemulsionanti (SMEDDS) del farmaco poco solubile in acquacefadroxil monoidrato. È stato esaminato l'impatto dell'olio, del tensioattivo e del co-surfattante sulla solubilità del farmaco e i loro rapporti sulla formazione di SMEDDS efficienti e stabili. Per la formulazione delle SMEDDS è stato utilizzato il metodo della titolazione in acqua. Gli SMEDDS sono stati caratterizzati mediante osservazione morfologica, dimensione dei globuli, misurazione del punto di nuvola, determinazione della viscosità, indice di rifrazione, % di trasmittanza, contenuto di farmaco degli SMEDDS di cefadroxil monoidrato e studio del rilascio in vitro. La formulazione ottimale F2 era composta da acido oleico, tween-80 e PEG-400 con un rapporto di miscelazione S:1. Il test di rilascio in vitro ha mostrato un rilascio completo di cefadroxil monoidrato dalle SMEDDS in circa 1,5 ore. Sono state preparate formulazioni orali di SMEDDS con cefadroxil monoidrato che forniscono un'eccellente solubilizzazione del farmaco e un migliore rilascio in vitro di cefadroxil monoidrato rispetto al prodotto marcato. La formulazione selezionata F2 è stata testata per studi farmacocinetici rispetto alla formulazione commercializzata e ha mostrato un aumento della biodisponibilità orale di cefadroxil monoidrato.

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