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Formulazione E Valutazione Della Nanosospensione Di Itraconazolo by Kavita Attri, Avneet Kaur

Formulazione E Valutazione Della Nanosospensione Di Itraconazolo

by Kavita Attri , Avneet Kaur
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Book cover type: Paperback
  • ISBN13: 9786209405549
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 108
  • Original Price: GBP 52.98
  • Language: Italian
  • Edition: N/A
  • Item Weight: 155 grams
  • BISAC Subject(s): General

La scarsa solubilit� in acqua dei principi attivi farmaceutici (API) rappresenta una sfida significativa nella somministrazione di farmaci per via orale, con conseguente riduzione della biodisponibilit� e compromissione dell'efficacia terapeutica. Questo studio si propone di affrontare questo problema sviluppando una nanosospensione ottimizzata di itraconazolo per la somministrazione intranasale, potenzialmente in grado di migliorare la disponibilit� del farmaco attraverso la barriera emato-encefalica.Le analisi FTIR e DSC hanno verificato la struttura chimica e lo stato cristallino del farmaco .Perottimizzare la formulazione � stato utilizzato il Box-Behnken Design, che ha permesso di ottenere nanoparticelle con dimensioni, indice di polidispersit�, potenziale zeta ed efficienza di intrappolamento favorevoli . Le immagini TEM hanno rivelato una struttura core-shell delle nanoparticelle. La nanosospensione ottimizzata ha dimostrato un migliore rilascio di farmaco rispetto a una sospensione convenzionale. Questi risultati suggeriscono che la nanosospensione di itraconazolo sviluppata ha il potenziale per migliorare la solubilit� e la biodisponibilit� del farmaco..

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