G Protein-Coxford Upled Receptors

Name: G Protein-Coxford Upled Receptors
Brand: Cambridge UP
SKU: 9780521112086
Price: 4104.0 INR
Availability: InStock

by Sandra Siehler

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ISBN13: 9780521112086
Binding: Hardcover
Subject: Bio-Science and Agriculture
Publisher: Cambridge UP
Publisher Imprint: Cambridge
Publication Date: June 4, 2010
Pages: 446
Original Price: USD 180.0
Language: English
Edition: N/A
Item Weight: 1080 grams
BISAC Subject(s): Biochemistry

About The Book

About the Book This text provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The first chapters of this book illustrate the history of GPCRs based on distinct species and genomic information. This is followed by discussion of the homo- and hetero-oligomerization features of GPCRs, including receptors for glutamate, GABAB, dopamine, and chemokines. Several chapters are devoted to the key signaling features of GPCRs. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically -adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field."

About The Author

Milligan, Graeme: - Dr Milligan is Professor of Molecular Pharmacology at the University of Glasgow. He is actively involved in numerous associations, such as the Biochemical Society and British Pharmacological Society. Dr Milligan was awarded the Ariens Award for Pharmacology from the Dutch Pharmacological Society in 2006.

Siehler, Sandra: - Dr Siehler is a Research Investigator at the Novartis Institute for Biomedical Research in Basel, Switzerland. Dr Siehler is a member of the American Society for Pharmacology and Experimental Therapeutics and the British Pharmacological Society.

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