Galusan epigalokatechiny chroni przed neurotoksycznością indukowaną fluorem

Name: Galusan epigalokatechiny chroni przed neurotoksycznością indukowaną fluorem
Brand: Wydawnictwo Nasza Wiedza
SKU: 9786208665241
Price: 3774.0 INR
Availability: InStock

by S. Thanga Pandiyan , S. Milton Prabu

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ISBN13: 9786208665241
Binding: Paperback
Subject: N/A
Publisher: Wydawnictwo Nasza Wiedza
Publisher Imprint: Wydawnictwo Nasza Wiedza
Publication Date: February 19, 2025
Pages: 52
Original Price: USD 42.0
Language: Polish
Edition: N/A
Item Weight: 82 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Ekspozycja na fluor (Fl) wywoluje neurodegenerację w m�zgu. Neuroprotekcyjna rola EGCG przeciwko neurotoksyczności indukowanej Fl w hipokampie szczura nie zostala jeszcze zbadana. W niniejszym badaniu skupiliśmy się na tym, czy EGCG (40 mg / kg) zapobiega stresowi oksydacyjnemu indukowanemu przez Fl w m�zgu szczur�w, ze szczeg�lnym uwzględnieniem hipokampa. Zatrucie Fl (25 mg / kg) przez 4 tygodnie wykazuje obniżone neuroprzekaźniki (AChE, NP, DA i 5-HT) w m�zgu. Markery stresu oksydacyjnego (ROS, TBARS, NO i PC) znacznie wzrosly wraz ze zmniejszeniem enzymatycznych (SOD, CAT, GPx, GR, GST i G6PD) i nieenzymatycznych przeciwutleniaczy (GSH, TSH i wit. C) w hipokampie szczur�w zatrutych Fl. Co więcej, szczury odurzone Fl wykazywaly apoptozę pośredniczoną przez szlak wewnętrzny i zewnętrzny w hipokampie szczur�w. Fl znacząco zwiększyl uszkodzenia DNA, o czym świadczy zwiększona fragmentacja DNA. Co więcej, toksyczny wplyw Fl na hipokamp zostal r�wnież udowodniony w badaniach immunohistochemicznych, histologicznych i ultrastrukturalnych. Wstępne podanie EGCG znacząco chronilo m�zg szczura i hipokamp przed Fl ROS dzięki jego silnym wlaściwościom przeciwutleniającym i zmiatającym wolne rodniki.

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