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Genes e câncer bucal by Raj V., Mohan

Genes e câncer bucal

by Mohan Raj V. , Chaya M. David , Ramnarayan B. K.
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Book cover type: Paperback
  • ISBN13: 9786208614850
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 152
  • Original Price: GBP 58.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 214 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

Neste livro, estudamos os genes envolvidos na carcinogênese oral e seu uso na terapia genética. A carcinogênese é um processo complexo e de várias etapas no qual os eventos genéticos nas vias de transdução de sinal que governam a fisiologia celular normal são quantitativamente alterados. A base genética do câncer está agora bem estabelecida. Em condições normais, estas vias excitatórias e inibitórias rigidamente controladas regulam a biologia dos queratinócitos orais. As funções celulares básicas sob esses controles incluem divisão celular, diferenciação, senescência e adesão. Fatores genéticos como oncogenes, genes supressores de tumor e genes reguladores são identificados como envolvidos na carcinogênese oral com esses fatores de risco de maneira dependente e independente. MiRNAs e Ras Oncogene são um dos mais frequentemente desregulados geneticamente no câncer bucal. A terapia genética para o câncer é responsável pela maioria dos ensaios clínicos de terapia genética. Os alvos para isso incluem a substituição de genes supressores de tumor, "genes suicidas" para ativar pró-drogas, transferência de genes baseados em genes antiangiogênicos.

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