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Geni e cancro orale by Raj V., Mohan

Geni e cancro orale

by Mohan Raj V. , Chaya M. David , Ramnarayan B. K.
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Book cover type: Paperback
  • ISBN13: 9786208614898
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 152
  • Original Price: GBP 58.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 214 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

In questo libro studiamo i geni coinvolti nella carcinogenesi orale e il loro utilizzo nella terapia genica. La cancerogenesi è un processo complesso a più fasi in cui gli eventi genetici all'interno delle vie di trasduzione del segnale che governano la normale fisiologia cellulare vengono alterati quantitativamente. La base genetica del cancro è ormai ben consolidata. In condizioni normali, queste vie eccitatorie e inibitorie strettamente controllate regolano la biologia dei cheratinociti orali. Le funzioni cellulari di base sotto questi controlli includono la divisione cellulare, la differenziazione, la senescenza e l'adesione. È stato identificato che fattori genetici come oncogeni, geni oncosoppressori e geni regolatori sono coinvolti nella carcinogenesi orale con questi fattori di rischio dipendenti e indipendenti. MiRNA e Ras L'oncogene è uno dei geni geneticamente deregolamentati più frequentemente nel cancro orale. La terapia genica per il cancro rappresenta la maggior parte degli studi clinici sulla terapia genica. Gli obiettivi a questo scopo includono la sostituzione di geni oncosoppressori, "geni suicidi" per attivare profarmaci, trasferimento genico basato su kine di geni antiangiogenici.

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