Granulocytopoese Unter Physiologischen Und Pathologischen Bedingungen

Name: Granulocytopoese Unter Physiologischen Und Pathologischen Bedingungen
Brand: Springer
SKU: 9783540035015
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ISBN13: 9783540035015
Binding: Paperback
Subject: N/A
Publisher: Springer
Publisher Imprint: Springer
Publication Date: January 1, 1966
Pages: 186
Original Price: EUR 51.39
Language: German
Edition: Softcover Repri
Item Weight: 286 grams
BISAC Subject(s): Physiology

About The Book

trachtigt wird, hangt vorwiegend von seiner Regenerationsintensitat ab, ftir die der Mitoseindex im fixierten Praparat sicher ein ausreichender MaBstab ist. Ftir Tumoren mit niedrigem Mitoseindex hat die alternierende hoch- dosierte Behandlung mit Cytostatica gtinstigere theoretische Voraussetzun- gen als die kontinuierliche, weil sich in der Zwischenzeit die Granulopoese durch Aktivierung aus ihren Reserven wieder erholen kann. E. Zusammenfassung In der vorliegenden Arbeit wird der Mechanismus der Entstehung der neutrophil en Granulocyten behandelt und eine neue Theorie tiber die Pro- liferation der Granulocytopoese entwickelt. Bei dem typischen Wechsel- gewebe, das verschiedene Reifungsstadien durchlauft, setzt sich im Gegen- satz zu vielen anderen Geweben die Proliferation aus Regeneration und Differenzierung zusammen. Die Beurteilung der Proliferationsaktivitat aus dem Knochenmark wird in vivo weiterhin durch die nicht tiberschaubare GroBe der Ausschwemmung erschwert. Daten tiber die morphologischen Veranderungen und Zeitverhaltnisse bei der Entwicklung der neutrophilen Granulocyten werden zusammenge- stellt und durch unsere experimentellen Untersuchungen an in vitro tiber- lebenden menschlichen Knochenmarkzellen erganzt. Durch direkte Beobach- tung mit dem Phasenkontrastmikroskop wurden Ergebnisse tiber die Dauer der Mitosen, der Interkinesen und der Reifung vom Promyelocyten zum Segmentkernigen gewonnen. Die reifende Granulopoese wies bei einem in vitro beobachteten Fall eine Reifungszeit vom Promyelocyten zum Segmentkernigen von 4 Tagen und eine Generationszeit von 30 Std auf, was bei der beobachteten Mitosedauer von 1 Std einer Mitoserate von 0,033 pro Stunde entspricht. 1m gefarbten Knochenmark- und Kulturausstrich wurden Zellen und Mitosephasen, auch unter Einwirkung von Spindelgiften, differenziert und die Ergebnisse statistisch ausgewertet. Der DNS-Stoff- wechsel der Zellen wurde durch Mikroautoradiographien bestimmt.

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