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Handbook of Molecular-Genetic Techniques for Brain and Behavior Research by Wim E. Crusio

Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

by Wim E. Crusio
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Book cover type: Hardcover
  • ISBN13: 9780444502391
  • Binding: Hardcover
  • Subject: N/A
  • Publisher: Elsevier Science
  • Publisher Imprint: Elsevier Science
  • Publication Date:
  • Pages: 962
  • Original Price: USD 230.0
  • Language: English
  • Edition: N/A
  • Item Weight: 2459 grams
  • BISAC Subject(s): Anthropology / Physical, Neurology, and Neuropsychology

The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples.

It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

Crusio, Wim E.: - Dr. Wim Crusio is a Research Director with the French National Centre for Scientific Research (Centre National de la Recherche Scientifique, CNRS) and adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine at the University of Bordeaux. Prior to this, he held positions as Professor of Psychiatry in the Brudnick Neuropsychiatric Research Institute at the University of Massachusetts Medical School and as senior researcher at the Universities of Heidelberg (Germany) and Paris V (France). He was one of the founders of the International Behavioural and Neural Genetics Society (IBANGS), founding editor-in-chief of Genes, Brain and Behavior (G2B), and associate editor or member of the editorial board of over a dozen scientific journals, including The Behavioral and Brain Sciences. He regularly serves as reviewer, both for scientific journals and for granting agencies, including the NIH, NSERC, European Union, and others. He is a recipient of the IBANGS Distinguished Service Award.

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