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Harnblasentumoren: Unter Berücksichtigung Experimenteller Befunde Zur Pathomorphogenese, Prophylaxe Und Therapie by H. -D Adolphs, J. Thiele, W. Vahlensieck

Harnblasentumoren: Unter Berücksichtigung Experimenteller Befunde Zur Pathomorphogenese, Prophylaxe Und Therapie

by H. -D Adolphs , J. Thiele , W. Vahlensieck
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Book cover type: Paperback
  • ISBN13: 9783798505506
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 207
  • Original Price: EUR 51.39
  • Language: German
  • Edition: N/A
  • Item Weight: 363 grams
  • BISAC Subject(s): Oncology / General

Die offenbar zunehmende Haufigkeit von Harnblasentumoren laf, t es gerechtfertigt erscheinen, einen zusammenfassenden Uberblick iiber alle damit verbundenen Pro- bleme zu versuchen, zumal die Literatur unter Einbeziehung der verschiedenen Fach- gebiete fast uniibersehbar geworden ist. Zur Inzidenz ist die Frage der Zunahme dieser Tumoren sowohl im Hinblick auf die gesteigerte Lebenserwartung als auch auf die mogliche Identifizierung neuer kanzerogener Substanzen zu klaren und zu erortern, inwieweit hier praventivmedi- zinische Maf, nahmen zu einer Verminderung der Manifestation und schlief, lich auch zu einer Friiherkennung beitragen konnen. Von Bedeutung ist in diesem Zusammen- hang auch die Darstellung der Geschlechtsverteilung, der Symptomatik sowie der modernen diagnostischen Verfahren. Abgesehen von der Friiherkennung, der Histo- logie, dem Malignitatsgrad und dem nach dem TNM-System zugeordneten Stadium des Tumors haben Art und Umfang der Behandlung fUr die Prognose eine entschei- dende Bedeutung. Wahrend iiber die operativen Maf, nahmen (TUR, Kryo-oder Laser-Therapie, Teil- resektion oder Zystektomie) beziiglich Indikation und Technik weitgehend Uberein- stirn mung besteht, sind viele Fragen der Bestrahlungsbehandlung und insbesondere einer adjuvant en medikamentOsen Therapie noch offen. In eigenen tierexperimentel- len Untersuchungen wurden Harnblasentumoren bei der Ratte durch ein chemisches Karzinogen (FANFT) induziert und die lichtmikroskopischen sowie ultrastrukturellen Veranderungen wahrend der Karzinogenese eingehend dargestellt. Unter Zugrunde- legung dieses experimentellen Systems wird ein eigenes Konzept zur Prophylaxe und Therapie dieser Harnblasentumoren gepriift; die mogliche klinische Bedeutung dieser Behandlungsform wird diskutiert. Gestiitzt auf die bisherigen Ergebnisse dieser Unter- suchungen und unter Beriicksichtigung der bereits vorliegenden klinischen Erfahrun- gen wird abschlief, end ein an dem TNM-System orientierter Behandlungsplan fUr Harnblasentumoren vorgestellt.

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