Il microambiente delle cellule staminali e i suoi effetti sul trattamento della leucemia

Name: Il microambiente delle cellule staminali e i suoi effetti sul trattamento della leucemia
Brand: Edizioni Sapienza
SKU: 9786209847851
Price: 8359.0 INR
Availability: InStock

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ISBN13: 9786209847851
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: March 31, 2026
Pages: 136
Original Price: GBP 66.0
Language: Italian
Edition: N/A
Item Weight: 191 grams
BISAC Subject(s): Life Sciences / Genetics & Genomics

About The Book

La leucemia linfoblastica acuta � una delle forme pi� comuni di leucemia che colpisce i bambini. Sebbene si sia registrato un notevole miglioramento nei tassi di guarigione, una percentuale di bambini continua a essere a rischio di morte a causa della resistenza ai farmaci o degli effetti collaterali tossici del trattamento. I glucocorticoidi, come il desametasone, vengono regolarmente utilizzati nel trattamento per i loro effetti pro-apoptotici. Recenti studi hanno evidenziato il ruolo delle cellule staminali del midollo osseo nello sviluppo della resistenza e nel fallimento del trattamento, con conseguente decesso del paziente. In questo libro, abbiamo dimostrato l'importanza di considerare in che modo la terapia farmacologica combinata differisce da quella con un singolo farmaco e come le cellule staminali del midollo osseo possano influenzare la resistenza ai farmaci. In conclusione, i nostri risultati possono aumentare la comprensione degli aspetti biologici e molecolari delle differenze tra le cellule sensibili e quelle resistenti nella leucemia linfoblastica acuta e dell'effetto della nicchia delle cellule staminali sulla terapia, il che pu� contribuire a una terapia pi� efficiente e meno tossica.

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