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Il ruolo della chirurgia nel carcinoma mammario in stadio precoce IV by Mouna Kouira, Ekram Guerbeg, Hafedh Abbessi

Il ruolo della chirurgia nel carcinoma mammario in stadio precoce IV

by Mouna Kouira , Ekram Guerbeg , Hafedh Abbessi
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Book cover type: Paperback
  • ISBN13: 9786209386329
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 100
  • Original Price: GBP 52.98
  • Language: Italian
  • Edition: N/A
  • Item Weight: 146 grams
  • BISAC Subject(s): General

Il carcinoma mammario metastatico precoce � una malattia aggressiva. Abbiamo condotto uno studio retrospettivo su 221 casi di carcinoma mammario in stadio IV per valutare il valore della chirurgia locale nel carcinoma mammario metastatico. Centoventinove pazienti sono state sottoposte a chirurgia. I margini di resezione sani sono stati ottenuti nel 76,1% dei casi. Le pazienti operate avevano uno stadio T meno avanzato (p=0,0001), meno metastasi viscerali (p=0,0001) e meno lesioni secondarie (p=0,001). Dopo un follow-up mediano di 36 mesi, la sopravvivenza globale a 1, 3 e 5 anni era migliore nel gruppo operato (p=0,0001, p=0,002, p=0,019). Nel caso di metastasi ossee isolate, i pazienti sottoposti a intervento chirurgico avevano una sopravvivenza globale migliore a 1, 3 e 5 anni rispetto a quelli non operati (p=0,02, p=0,037, p=0,033). La tecnica chirurgica non ha avuto alcun impatto sulla sopravvivenza globale o sulla recidiva locale. La chirurgia in sano ha migliorato la OS a 5 anni (p=0,047). All'analisi multivariata, i fattori che influenzavano l'esito chirurgico erano la presenza di metastasi viscerali, pi� di 3 metastasi e i limiti di resezione del tumore.

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