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Immunizzazione dalla carie dentale by Ghune, Divya

Immunizzazione dalla carie dentale

by Divya Ghune , Aarti Patil
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Book cover type: Paperback
  • ISBN13: 9786208548735
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 80
  • Original Price: USD 45.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): Dentistry / General

La vaccinazione contro la carie dentale si riferisce allo sviluppo di vaccini volti a prevenire la carie dentale (carie), una malattia cronica causata principalmente dallo Streptococcus mutans e da altri batteri cariogeni. Questi batteri metabolizzano gli zuccheri nella cavità orale, producendo acidi che demineralizzano lo smalto dei denti e portano alla carie. I vaccini contro la carie dentale mirano a stimolare il sistema immunitario a produrre anticorpi che neutralizzano i fattori di virulenza di S. mutans, come gli enzimi glucosiltransferasi, fondamentali per la formazione del biofilm e la produzione di acidi. Le strategie di immunizzazione comprendono vaccini attivi che scatenano la risposta immunitaria dell'organismo e l'immunizzazione passiva che utilizza anticorpi preformati. Sebbene la ricerca in questo campo si sia dimostrata promettente, con diversi vaccini candidati che hanno dimostrato efficacia negli studi preclinici e clinici iniziali, permangono sfide quali la sicurezza, i costi e le considerazioni etiche. Lo sviluppo di un vaccino efficace contro la carie dentale potrebbe ridurre significativamente l'onere globale della carie, in particolare nelle popolazioni poco servite che non hanno accesso a cure dentistiche adeguate.

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