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Immunoinformatyka by Amr Badr, Emad Nabil

Immunoinformatyka

by Amr Badr , Emad Nabil
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Book cover type: Paperback
  • ISBN13: 9786209500787
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Publication Date:
  • Pages: 108
  • Original Price: GBP 58.0
  • Language: Polish
  • Edition: N/A
  • Item Weight: 155 grams
  • BISAC Subject(s): General

Identyfikacja peptyd�w wiążących się z gl�wnym kompleksem zgodności tkankowej (MHC) jest ważnym krokiem w wyborze kandydat�w na epitopy kom�rek T, kt�re nadają się do wykorzystania w nowych szczepionkach. Rowek wiązania cząsteczki MHC klasy II jest otwarty po obu stronach, co pozwala na dużą zmiennośc dlugości peptyd�w wiążących się z tą cząsteczką, a w konsekwencji utrudnia przewidywanie motywu rdzenia wiązania. Dokladne i wydajne podejście obliczeniowe do przewidywania takich peptyd�w może znacznie skr�cic czas i obniżyc koszty związane z projektowaniem nowych szczepionek. EpiGASVM, nowe podejście do komputerowego przewidywania epitop�w MHC klasy II, zostalo opracowane poprzez polączenie algorytm�w genetycznych i maszyn wektor�w nośnych. Dziewięc wariant�w EpiGASVM zastosowano do dw�ch zestaw�w danych por�wnawczych o zmniejszonym podobieństwie. Dokladnośc przewidywania i obszar pod krzywą charakterystyki operacyjnej odbiornika zostaly obliczone jako miary wydajności. Technika ta zostala por�wnana z niekt�rymi najnowocześniejszymi technikami w tej dziedzinie (np. ARB, SMM-Align, PROPRED, NN-Align). Wyniki pokazują, że EpiGASVM jest obiecującą nową techniką rozwiązywania problemu przewidywania epitop�w MHC klasy II.

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