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Imunização contra a cárie dentária by Ghune, Divya

Imunização contra a cárie dentária

by Divya Ghune , Aarti Patil
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Book cover type: Paperback
  • ISBN13: 9786208548711
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 80
  • Original Price: USD 45.0
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 118 grams
  • BISAC Subject(s): Dentistry / General

A imunização contra a cárie dentária refere-se ao desenvolvimento de vacinas destinadas a prevenir a cárie dentária (cárie dentária), uma doença crónica causada principalmente pelo Streptococcus mutans e outras bactérias cariogénicas. Estas bactérias metabolizam os açúcares na cavidade oral, produzindo ácidos que desmineralizam o esmalte dos dentes e conduzem à cárie. As vacinas contra a cárie dentária têm como objetivo estimular o sistema imunitário a produzir anticorpos que neutralizem os factores de virulência do S. mutans, como as enzimas glucosiltransferase, que são fundamentais para a formação do biofilme e a produção de ácido. As estratégias de imunização incluem vacinas activas que desencadeiam a resposta imunitária do organismo e imunização passiva utilizando anticorpos pré-formados. Embora a investigação neste domínio se tenha revelado promissora, com várias vacinas candidatas a demonstrarem eficácia em estudos pré-clínicos e clínicos iniciais, subsistem desafios como a segurança, o custo e considerações éticas. O desenvolvimento de uma vacina eficaz contra a cárie dentária poderia reduzir significativamente o peso global da cárie dentária, particularmente em populações carenciadas que não têm acesso a cuidados dentários adequados.

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