Integration of Pharmaceutical Discovery and Development: Case Histories

Name: Integration of Pharmaceutical Discovery and Development: Case Histories
Brand: Springer
SKU: 9780306457432
Price: 22595.0 INR
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by Ronald T. Borchardt , Roger M. Freidinger , Tomi K. Sawyer

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ISBN13: 9780306457432
Binding: Hardcover
Subject: N/A
Publisher: Springer
Publisher Imprint: Springer
Publication Date: August 31, 1998
Pages: 610
Original Price: USD 219.99
Language: English
Edition: 1998
Item Weight: 1066 grams
BISAC Subject(s): Pharmacology

About The Book

In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g., high affinity and specificity for the target receptor), pharmaceutical (e. g., solubility and chemical stability), bioph- maceutical (e. g., cell membrane permeability), and metabolic/pharmacokinetic (e. g., metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g., medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g., analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.

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