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Interconnexion entre marques épigénétiques by Denis-H

Interconnexion entre marques épigénétiques

by Denis-H
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Book cover type: Paperback
  • ISBN13: 9786131534898
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 200
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 300 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

Le séquençage de nombreux génomes eucaryotes indique que l'augmentation de la "biocomplexité" au cours de l'évolution n'est pas directement corrélée à l'accroissement du nombre de gènes. A cet égard, il semble de plus en plus clair que l'épigénétique est riche d'une information qui se superpose à celle du code génétique. L'information épigénétique est principalement véhiculée par des modifications de l'ADN et des histones. La modification majeure de l'ADN est la méthylation de la cytosine. Quant aux histones, différentes modifications posttraductionnelles, régulées de façon dynamique et réversible, ont été décrites, comme l'acétylation, la phosphorylation et la méthylation. Dans cet ouvrage, nous nous sommes intéressés à la déméthylase PADI4 (peptidylarginine déiminase 4) qui convertit des résidus arginines des histones en résidus citrullines, ce qui a pour conséquence d'entraîner une répression transcriptionnelle. Ce livre devrait aider à mieux cerner comment la première histone déméthylase décrite, PADI4, verrouille l'expression génique.

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