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Kidney in Essential Hypertension: Proceedings of the Course on the Kidney in Essential Hypertension Held at New Orleans, Louisiana, March 18-19, 1983 by Franz H. Messerli

Kidney in Essential Hypertension: Proceedings of the Course on the Kidney in Essential Hypertension Held at New Orleans, Louisiana, March 18-19, 1983

by Franz H. Messerli
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Book cover type: Paperback
  • ISBN13: 9781461338994
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 260
  • Original Price: EUR 99.99
  • Language: English
  • Edition: 1984
  • Item Weight: 421 grams
  • BISAC Subject(s): General, Cardiology, and Nephrology

The kidney, similar to the heart, plays a three-fold role in essential hypertension. First, it participates in the patho- genesis of arterial hypertension. Second, it suffers as a target organ of long-standing hypertension, and third, it experiences the effects of antihypertensive therapy. Perhaps most contested at the present time is the involvement of the kidney in the patho- genesis of essential hypertension. More than a century ago, William Osler put forward three basic hypotheses about the "genuine contracted kidney. "l 1. "The hypertrophy can be regarded as an effect to overcome a sort of stop-cock action of the vessels when under the influence of an irritating ingredient in the blood greatly contracted and increased the peripheral resistance. " Clearly this hypothesis of an "irritating ingredient" is perhaps the most convincing nowadays, and numerous attempts have been made to identify a specific vasoconstrictive agent in the blood in essential hypertension. 2. "The obliteration of a large number of capillary territories in the kidney materially raised the arterial pressure. An additional factor of dimin- ished excretion of water also heightened the pressure within the blood vessel. " Today we know that fluid volume overload in the presence of reduced renal mass seems to be the most likely mechanism accoun- ting for renal parenchymal hypertension and, as shown by Guyton's group, for certain forms of experimental hypertension. 3.

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