La réponse immunitaire du chat à l'infection par le FeLV
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Des informations sont présentées sur les différents aspects de la réponse immunitaire humorale et cellulaire résultant de l'interaction du chat avec le FeLV. La réponse immunitaire doit être efficace et spécifique dès le moment où le chat entre en contact avec le virus. L'immunité cellulaire et humorale est responsable du contrôle de l'infection, les anticorps arrêtent la propagation du virus et établissent une résistance à l'infection, les lymphocytes (cellulaires) sont responsables de l'élimination des cellules infectées et de la protection contre le développement d'une infection latente, de sorte que la qualité et l'ampleur de ces deux mécanismes détermineront l'évolution de l'infection. Les rétrovirus peuvent altérer ces mécanismes, le résultat de l'interaction avec le virus ne repose pas uniquement sur la réponse immunitaire, il existe des facteurs spécifiques au virus: le sous-type viral et la concentration ainsi que l'interaction de ces facteurs déterminent l'évolution de l'infection, si la réponse immunitaire est faible ou absente, l'hôte développe une infection progressive avec une virémie persistante et le développement de maladies associées au FeLV qui peuvent être fatales. Il est essentiel de connaître le statut rétroviral du chat et les facteurs de risque associés.
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