Le microenvironnement des cellules souches et ses effets sur le traitement de la leucémie
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La leuc�mie lymphoblastique aigu� est l'une des formes les plus courantes de leuc�mie chez l'enfant. Bien que l'on observe des progr�s remarquables en mati�re de taux de gu�rison, un certain pourcentage d'enfants reste expos� � un risque de d�c�s en raison d'une r�sistance aux m�dicaments ou des effets secondaires toxiques du traitement. Les glucocortico�des, tels que la dexam�thasone, sont couramment utilis�s dans le traitement en raison de leurs effets pro-apoptotiques. Des �tudes r�centes ont mis en �vidence le r�le des cellules souches de la moelle osseuse dans le d�veloppement d'une r�sistance et l'�chec du traitement, pouvant entra�ner le d�c�s du patient. Dans cet ouvrage, nous avons d�montr� l'importance de prendre en compte les diff�rences entre un traitement m�dicamenteux combin� et un traitement m�dicamenteux individuel, ainsi que la mani�re dont les cellules souches de la moelle osseuse peuvent influencer la r�sistance aux m�dicaments. En conclusion, nos r�sultats peuvent am�liorer la compr�hension des aspects biologiques et mol�culaires des diff�rences entre les cellules sensibles et r�sistantes dans la leuc�mie lymphoblastique aigu�, ainsi que de l'effet de la niche des cellules souches sur le traitement, ce qui peut contribuer � une th�rapie plus efficace et moins toxique.
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