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Liens neuroendocriniens et neurotrophiques entre la ménopause et le risque by Heba Hassan, Mona El-Banna

Liens neuroendocriniens et neurotrophiques entre la ménopause et le risque

by Heba Hassan , Mona El-Banna
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Book cover type: Paperback
  • ISBN13: 9786139620210
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 144
  • Original Price: GBP 59.94
  • Language: French
  • Edition: N/A
  • Item Weight: 200 grams
  • BISAC Subject(s): Life Sciences / Biology

Les maladies neurod�g�n�ratives (MN), dont la maladie d'Alzheimer et la maladie de Parkinson, se caract�risent par une perte neuronale progressive qui entra�ne des d�ficiences cognitives et motrices. La pr�valence et la progression de ces maladies sont nettement diff�rentes selon le sexe, et de plus en plus d'�l�ments indiquent que la m�nopause est un facteur d�terminant de la vuln�rabilit� des femmes. La baisse des oestrog�nes, de la progest�rone et d'autres facteurs neurotrophiques pendant la m�nopause perturbe de nombreux processus neuroprotecteurs, contribuant ainsi � l'apparition et � la progression de la maladie.Cet ouvrage met en lumi�re les principaux m�canismes pathologiques qui sous-tendent les MN, tels que le mauvais repliement des prot�ines, le stress oxydatif, le dysfonctionnement mitochondrial, la neuroinflammation, l'apoptose, la susceptibilit� g�n�tique et l'alt�ration de la barri�re h�mato-enc�phalique. Il met l'accent sur les r�les modulateurs des hormones sexuelles et du facteur de croissance analogue � l'insuline-1 (IGF-1) par le biais de voies de signalisation g�nomiques et non g�nomiques qui r�gulent la survie neuronale et l'hom�ostasie c�r�brale. Dans l'ensemble, la m�nopause est pr�sent�e comme une transition biologique cruciale qui accro�t la susceptibilit� aux maladies neurod�g�n�ratives en perturbant les r�seaux neuroendocriniens et neurotrophiques interconnect�s.

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