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Manejo atual da leucemia mielóide crônica by Nadjat Siali

Manejo atual da leucemia mielóide crônica

by Nadjat Siali , Nadia Fettal
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Book cover type: Paperback
  • ISBN13: 9786207833566
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 148
  • Original Price: GBP 59.94
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 209 grams
  • BISAC Subject(s): General

A leucemia miel�ide cr�nica constitui um modelo em Onco-hematologia, porque foi a primeira anomalia cromoss�mica descrita numa doen�a maligna, mas cuja leucemog�nese tem sido particularmente bem estudada, permitindo assim grandes avan�os terap�uticos. Est� associada a uma anomalia gen�tica recorrente: o cromossomo Filad�lfia, transloca��o rec�proca balanceada t (9; 22), que resulta em um gene de fus�o BCR-ABL, depois uma prote�na anormal com atividade tirosina quinase, respons�vel pela transforma��o leuc�mica. � tamb�m a primeira doen�a em que a terapia molecular direcionada foi utilizada com sucesso; incluindo imatinibe; esses TKIs apresentaram a maioria das muta��es, exceto a temida muta��o T315I. Isto levou os cientistas a desenvolver um TKI de terceira gera��o; � Ponatinibe. Esses tratamentos ambulatoriais permitiram melhores respostas hematol�gicas, citogen�ticas e moleculares, associadas a uma melhor qualidade de vida dos pacientes. No entanto, os TKIs n�o erradicam a doen�a. No entanto, o transplante alog�nico de c�lulas-tronco hematopoi�ticas continua sendo o �nico tratamento curativo atualmente.

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