Marcatori biologici dei pazienti sottoposti a chirurgia bariatrica
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Lo studio ha valutato il comportamento dei livelli plasmatici di IGF-1, glucosio e insulina nel periodo pre- e post-operatorio di 45 pazienti sottoposti a chirurgia Fobi-Capella, suddivisi in 4 gruppi: non obesi, pre-operatori, post-operatori a 45 giorni e post-operatori a 1 anno. � stato osservato che il peso medio e il BMI sono diminuiti significativamente dopo un anno dall'intervento. I livelli di IGF-1 erano pi� bassi nei pazienti obesi rispetto a quelli eutrofici; dopo 45 giorni dall'intervento si � registrato un ulteriore calo del 30,1% e; i pazienti a un anno dall'intervento avevano una media simile a quella dei pazienti non obesi (251,50 98,72ng/mL e 329,09 89,83ng/mL). Il punteggio IGF-1 ha seguito le tendenze osservate in precedenza. I valori glicemici post-operatori a 45 giorni (86,18 8,53mg/dL) e a 1 anno (82,50 9,19mg/dL) erano inferiori a quelli pre-operatori (94,54 23,70mg/dL) e i gruppi a 1 anno e non obesi erano simili. I livelli medi di insulina nei pazienti a 45 giorni (9,26 4,86u/mL) e a un anno (6,71 4,41u/mL) dall'intervento erano inferiori a quelli riscontrati prima dell'intervento (62,56 47,53u/mL) e simili a quelli del gruppo non obeso. L'HOMA-IR � diminuito nei gruppi post-operatori rispetto al gruppo pre-operatorio.
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