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Marqueurs moléculaires et thérapies ciblées by Dufort-S

Marqueurs moléculaires et thérapies ciblées

by Dufort-S
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Book cover type: Paperback
  • ISBN13: 9786131534256
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 140
  • Original Price: GBP 44.0
  • Language: French
  • Edition: N/A
  • Item Weight: 214 grams
  • BISAC Subject(s): Pharmacology

Les cancers broncho-pulmonaires et colorectaux sont les deux premi�res causes de mortalit� par cancer. D�tect�s tardivement, ils sont de tr�s mauvais pronostic, avec une survie � 5 ans respectivement de 12% et 5%. R�cemment, de nouvelles th�rapies dites cibl�es, telles les anticorps monoclonaux anti-EGFR ou les inhibiteurs de l''activit� tyrosine kinase de l''EGFR, ont �t� d�velopp�es. Une faible proportion des patients porteurs d''un cancer broncho-pulmonaire ou colorectal r�pond � ces traitements; leur survie est augment�e et leur qualit� de vie am�lior�e. Diff�rentes �tudes ont permis de pr�ciser les facteurs pr�dictifs de r�ponse, tels que les mutations des exons 18 � 21 de l''EGFR et celles de l''exon 1 de KRAS. Ainsi, les anticorps monoclonaux sont indiqu�s dans le traitement du cancer colorectal m�tastatique lorsque KRAS est sauvage. Pour le traitement des CBNPC par TKIs, le statut mutationnel de l''EGFR est en cours d''�valuation. Au laboratoire, l''analyse des mutations est r�alis�e par pyros�quen�age. Cette m�thode est sensible, rapide et relativement peu co�teuse, et permet une prise en charge optimale des patients pouvant b�n�ficier d''une th�rapie ciblant l''EGFR.

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