Mechanismen der adaptiven Immunität bei Ratten gegen eine Infektion mit E. coli O157: H7
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Die Reaktion eines Wirts auf einen bestimmten Erreger kann sowohl das unspezifische (angeborene) als auch das spezifische (erworbene) Immunsystem betreffen. Die spezifischen Komponenten passen sich an jede neu auftretende Krankheit an und sind in der Lage, eine erregerspezifische Immunit�t aufzubauen. Die Verbreitung von Escherichia coli O157: H7 hat seit ihrer ersten Beschreibung zugenommen, und trotz aller Bek�mpfungsma nahmen stellt sie nach wie vor ein ernstes Gesundheitsrisiko dar. Sie gilt als weltweite Bedrohung, nicht nur wegen ihrer steigenden Inzidenz, sondern auch wegen der Schwere der klinischen Komplikationen w�hrend der Behandlung, insbesondere ihrer Resistenz gegen Antibiotika. Es ist notwendig, die Infektion auf zellul�rer Ebene zu untersuchen, d. h. die Rolle verschiedener Zellen des Immunsystems bei der Bek�mpfung der Infektion, da dies als Leitfaden f�r die Art des Impfstoffs dient, der gegen die Infektion hergestellt werden soll.
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