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Melatonin, Neuroprotective Agents and Antidepressant Therapy by Francisco López-Muñoz

Melatonin, Neuroprotective Agents and Antidepressant Therapy

by Francisco López-Muñoz
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Book cover type: Paperback
  • ISBN13: 9788132238423
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 921
  • Original Price: EUR 229.99
  • Language: English
  • Edition: Softcover Repri
  • Item Weight: 1955 grams
  • BISAC Subject(s): Neurology, Psychiatry / Psychopharmacology, and Internal Medicine

From the Back Cover
This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agentslike agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects.

Prof.Venkataramanujan Srinivasan, Msc, Ph.D MAMS SRI SATHYA SAI MEDICAL EDUCATIONAL AND RESEARCH FOUNDATION An International Medical Sciences Research Study Center "PrasanthiNilayam", KOVAI, Coimbatore, Tamilnadu, INDIA

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