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Modulation de la Réponse Immunitaire Par Des Glycolipides Parasitaires by Debierre-Grockiego-F

Modulation de la Réponse Immunitaire Par Des Glycolipides Parasitaires

by Debierre-Grockiego-F
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Book cover type: Paperback
  • ISBN13: 9786131536410
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 64
  • Original Price: GBP 24.0
  • Language: French
  • Edition: N/A
  • Item Weight: 105 grams
  • BISAC Subject(s): Life Sciences / Biology

Ce travail est une synthèse des connaissances des effets biologiques des glycosylphosphatidylinositols (GPIs, glycolipides majoritaires à la surface des parasites apicomplexes) chez l'hôte. Les GPIs de Toxoplasma gondii (T. gondii, responsable de la toxoplasmose) induisent la production de cytokines inflammatoires par les macrophages. Cette production est dépendante de l'expression des récepteurs Toll-like TLR2 et TLR4, et de la galectine-3. Au contraire, certains acides gras de Plasmodium falciparum (P. falciparum, responsable du paludisme) et de T. gondii sont capables d'inhiber l'effet inflammatoire induit par les GPIs de ces parasites en diminuant l'activation de kinases et du facteur de transcription NF-kappaB. Les acides gras pourraient ètre un moyen de réduire la réponse inflammatoire in vivo. Les GPIs de T. gondii augmentent l'expression des molécules du complexe majeur d'histocompatibilité par les macrophages et les GPIs de P. falciparum induisent l'apoptose des cellules musculaires cardiaques. Les GPIs peuvent ètre utilisés pour produire des anticorps protecteurs dans une stratégie de vaccin anti-maladie .

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