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Modulation de l''angiogenèse tumorale by Haghighirad-F

Modulation de l''angiogenèse tumorale

by Haghighirad-F
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Book cover type: Paperback
  • ISBN13: 9786131555817
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Univ Europeenne
  • Publisher Imprint: Univ Europeenne
  • Publication Date:
  • Pages: 176
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 268 grams
  • BISAC Subject(s): General

La n�o-angiogen�se, formation de nouveaux vaisseaux � partir des cellules endoth�liales, est essentielle � la croissance des tumeurs malignes. Le VEGF est un des facteurs de croissance principaux de l''angiogen�se. Par ailleurs, l''�rythropo��tine (Epo), le facteur de croissance principal des �rythroblastes, est aussi impliqu� dans l''angiogen�se tumorale. L''expression du VEGF et de l''Epo est sous le contr�le du facteur de transcription HIF (Hypoxia inducible factor), et la concentration de ce facteur dans le milieu biologique est r�gul�e par le VHL (Von Hippel-Lindau). Des cellules en hypoxie ayant leur g�ne VHL inactiv� accumulent un haut niveau d''expression de HIF, qui active la transcription d''une vari�t� des g�nes dont VEGF et Epo. En �tudiant un cas de cancer du rein m�tastatique � cellules claires, nous avons identifi� deux nouvelles mutations somatiques et non conservatrices dans le g�ne du VHL du g�nome des cellules de la tumeur. La concentration importante d''Epo s�rique chez ce patient pourrait �tre � l''origine de la pr�sence d''un grand nombre de cellules endoth�liales mobilis�es dans le sang, ce qui pourrait expliquer la croissance rapide de la tumeur chez ce patient.

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