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Molecole della dengue: rivisitazione degli inibitori della proteasi NS2B/NS3 by Sérgio Modesto Vechi, Crislania Dos Santos

Molecole della dengue: rivisitazione degli inibitori della proteasi NS2B/NS3

by Sérgio Modesto Vechi , Crislania Dos Santos
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Book cover type: Paperback
  • ISBN13: 9786209482151
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 25.14
  • Language: Italian
  • Edition: N/A
  • Item Weight: 109 grams
  • BISAC Subject(s): Pharmacology

La dengue � un problema di salute pubblica di rilevanza mondiale ed � diventata nota come una delle pi� importanti arbovirosi che colpiscono l'uomo al giorno d'oggi, con epidemie ricorrenti nelle regioni tropicali dell'Asia, dell'Africa e delle Americhe. Sono stati compiuti grandi sforzi nella ricerca di trattamenti per la dengue, ma non esiste ancora alcun antivirale disponibile sul mercato per il trattamento di questa patologia. Tra le strategie che sono state utilizzate per lo sviluppo di antivirali contro la dengue, spicca l'inibizione del complesso NS2B/NS3pro. In questo contesto, questo lavoro di revisione descrive la dengue e le molecole correlate al virus della dengue, come le proteine virali e i loro inibitori, in particolare quelli della proteasi NS3 legata al suo cofattore NS2B (NS2B-NS3pro). Inoltre, le propriet� di diverse classi di inibitori vengono confrontate attraverso il calcolo dei loro descrittori molecolari.

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