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Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies by Mark Chang

Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies

by Mark Chang
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Book cover type: Paperback
  • ISBN13: 9781138374386
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Taylor & Francis
  • Publisher Imprint: CRC Press
  • Publication Date:
  • Pages: 564
  • Original Price: GBP 67.99
  • Language: English
  • Edition: N/A
  • Item Weight: 1050 grams
  • BISAC Subject(s): Biostatistics, Probability & Statistics / General, and Applied

Helping you become a creative, logical thinker and skillful "simulator," Monte Carlo Simulation for the Pharmaceutical Industry: Concepts, Algorithms, and Case Studies provides broad coverage of the entire drug development process, from drug discovery to preclinical and clinical trial aspects to commercialization. It presents the theories and methods needed to carry out computer simulations efficiently, covers both descriptive and pseudocode algorithms that provide the basis for implementation of the simulation methods, and illustrates real-world problems through case studies.

The text first emphasizes the importance of analogy and simulation using examples from a variety of areas, before introducing general sampling methods and the different stages of drug development. It then focuses on simulation approaches based on game theory and the Markov decision process, simulations in classical and adaptive trials, and various challenges in clinical trial management and execution. The author goes on to cover prescription drug marketing strategies and brand planning, molecular design and simulation, computational systems biology and biological pathway simulation with Petri nets, and physiologically based pharmacokinetic modeling and pharmacodynamic models. The final chapter explores Monte Carlo computing techniques for statistical inference.

This book offers a systematic treatment of computer simulation in drug development. It not only deals with the principles and methods of Monte Carlo simulation, but also the applications in drug development, such as statistical trial monitoring, prescription drug marketing, and molecular docking.

Mark Chang is the executive director of biostatistics and data management at AMAG Pharmaceuticals in Lexington, Massachusetts. Dr. Chang is an elected fellow of the American Statistical Association. He is the author of the best-selling Adaptive Design Theory and Implementation Using SAS and R and co-author of the best-selling Adaptive Design Methods in Clinical Trials.

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