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Myeloid Leukemia: Methods and Protocols by Harry Iland, Mark Hertzberg, Paula Marlton

Myeloid Leukemia: Methods and Protocols

by Harry Iland , Mark Hertzberg , Paula Marlton
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Book cover type: Hardcover
  • ISBN13: 9781588294852
  • Binding: Hardcover
  • Subject: N/A
  • Publisher: Humana
  • Publisher Imprint: Humana
  • Publication Date:
  • Pages: 307
  • Original Price: USD 109.99
  • Language: English
  • Edition: 2006
  • Item Weight: 663 grams
  • BISAC Subject(s): Oncology / General

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.

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