This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues.
Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends.
This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.
Dr. Emilio I. Alarcon is a Scientist in the Division of Cardiac Surgery at the University of Ottawa Heart Institute, where he directs the Bio-nanomaterials Chemistry and Engineering Laboratory (www.beatsresearch.com). He is also an Assistant Professor at the Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine at University of Ottawa. His unique research program, directly engaging with medical specialists, works to redefine translational medicine, bridging fundamental and applied sciences such as chemistry, mathematics, and nanotechnology to the development of novel bionanomaterials for treating patients with failing organs and tissues. Dr. Alarcon has already published over 72 articles all in prestigious peer-reviewed journals and several book chapters. Dr. Alarcon's distinctive discipline-bridging research has been funded by the largest Canadian agencies including the Natural Sciences and Engineering Research Council of Canada (NSERC), the Canadian Institutes of Health Research (CIHR), the New Frontiers in Research Fund (NFRF), the Ontario Institute for Regenerative Medicine (OIRM), and the Ministry of Economic Development, Job Creation and Trade of the Government of Ontario. Manuel Ahumada, Ph.D. is Principal Investigator at the Center for Applied Nanotechnology (CNAP) and an Assistant Professor at the Faculty of Sciences at the Universidad Mayor. In 2011, he received his B.Sc. in Chemistry at the Universidad de Santiago de Chile exploring the diffusion of solutes throughout the lipid bilayer. He obtained his Ph.D. in Chemistry in 2016 at the same institution, going more rooted in the study of phenomena's that modify the diffusion throughout the bilayer. In the same year, he moved to Ottawa (ON, Canada) as a postdoctoral fellow at the University of Ottawa Heart Institute, designing and developing bionanomaterials. In 2018, he joined as a postdoctoral fellow at the Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School (Boston, MA, United States) working on tissue bioengineering. Dr. Ahumada has published multiple peer-reviewed articles, book chapters, participated in international conferences and honored with several national and international prizes, scholarships, and research funding.
