Neoplasie ematologiche e ruolo della proteina Rab7

Name: Neoplasie ematologiche e ruolo della proteina Rab7
Brand: Edizioni Sapienza
SKU: 9786200749499
Price: 3462.0 INR
Availability: InStock

by Naveed Ullah , Sami Ullah , Muhammad Idrees

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ISBN13: 9786200749499
Binding: Paperback
Subject: N/A
Publisher: Edizioni Sapienza
Publisher Imprint: Edizioni Sapienza
Publication Date: July 23, 2025
Pages: 52
Original Price: GBP 31.23
Language: Italian
Edition: N/A
Item Weight: 82 grams
BISAC Subject(s): General

About The Book

La disregolazione della segnalazione dei fattori di crescita � una delle principali cause delle neoplasie ematologiche. Rab 7 svolge un ruolo importante nel traffico dei recettori dei fattori di crescita. Questo studio � stato condotto per verificare se l'inibizione della proteina Rab 7 influisce sulla segnalazione dei recettori dei fattori di crescita. L'inibizione di Rab 7 pu� aumentare la fosforilazione di ERK 1/2 indotta dall'IGF in modo pi� forte e sostenibile, mentre l'EGF promuove l'attivazione di ERK 1/2 ma non in modo cos� forte come l'IGF. Ci� significa che Rab 7 svolge un ruolo importante e cruciale nella regolazione del traffico dei recettori dei fattori di crescita mantenendo l'omeostasi cellulare. D'altra parte, difetti o alterazioni della proteina Rab7 dovuti a mutazioni del suo gene causate da fattori interni o esterni provocano un'alterazione della segnalazione dei recettori dei fattori di crescita. Le proteine Rab e i fattori regolatori associati sono spesso bersaglio di mutazioni e/o alterazioni dell'espressione in una variet� di neoplasie ematologiche. Qualsiasi fattore che provochi un cambiamento nella Rab 7, sia esso interno o esterno, � responsabile della disregolazione della segnalazione dei recettori dei fattori di crescita, che porta a una proliferazione cellulare incontrollata e, in ultima analisi, a neoplasie ematologiche.

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